Abstract Library

#406 YF476, a Gastrin Receptor Antagonist, Causes Regression of Tumors and Normalizes Serum Chromogranin A in Patients with Type 1 Gastric Carcinoids

Introduction: Chronic atrophic gastritis (CAG) results in achlorhydria, hypergastrinemia and, in some patients, gastric carcinoids (type 1 GCs). Type 1 GCs may become malignant and metastasize. Current treatments of type 1 GCs, such as polypectomy, somatostatin analogues and antrectomy, have their disadvantages. YF476 – a potent, selective, orally active and well-tolerated gastrin receptor antagonist in pre-clinical studies – prevented, as well as reduced, the number and size of gastric carcinoids and carcinomas in rodent models.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Fossmark R, Sørdal �, Jianu C, Qvigstad G, Boyce M,

Keywords: gastric carcinoids, gastrin, chromogranin A,

#295 Unusual Behavior of Gastric Carcinoid Type 1

Introduction: Gastric carcinoids (GC) are rare tumors of the stomach. GC type 1 are associated with chronic atrophic gastritis (CAG) and are the most benign type, having low metastatic potential.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Spampatti M, Massironi S, Rossi R, Conte D, Ciafardini C,

Keywords: gastric carcinoid type 1, metastatic disease, well-differentiated endocrine tumors, Ki-67index,

#263 Chronic Atrophic Gastritis Associated with Hyperparathyroidism: A prospective Study

Introduction: The association of gastric carcinoids (GCs) type 1 and hyperparathyroidism (HPTH) has been reported, whereas a possible association between chronic atrophic gastritis (CAG) and HPTH is still scant.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Massironi S, Rossi R, Spampatti M, Conte D, Verga U,

Keywords: chronic atrophic gastritis (CAG), hyperparathyroidism (HPTH), gastric carcinoids ,